Human functional protein association network from STRING (version 10).

Description

An igraph object that contains a functional protein association network in human. The network is extracted from the STRING database (version 10). Only those associations with medium confidence (score>=0.4) are retained.

Usage

org.Hs.string <- dRDataLoader(RData = "org.Hs.string")

Value

an object of class "igraph" (see http://igraph.org/r/doc/aaa-igraph-package.html). It has attributes for both vertices and edges. Below are attributes for the vertices:

  • name: unique id for the vertices
  • seqid: protein seqid for the vertices
  • geneid: Entrez geneid (if any) for the vertices
  • symbol: gene symbol (if any) for the vertices
  • description: gene description (if any) for the vertices

Below are attributes for the edges:

  • neighborhood_score: predictive score based on neighborhood data
  • fusion_score: predictive score based on fusion data
  • cooccurence_score: predictive score based on cooccurence data
  • coexpression_score: predictive score based on coexpression
  • experimental_score: predictive score based on experimental data
  • database_score: predictive score based on database
  • textmining_score: predictive score based on text mining
  • combined_score: combined score from all above predictive scores

References

Szklarczyk et al. (2015) STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res, 43:D447-52.

Examples

org.Hs.string <- dRDataLoader(RData='org.Hs.string')
'org.Hs.string' (from https://github.com/hfang-bristol/RDataCentre/blob/master/dnet/1.0.7/org.Hs.string.RData?raw=true) has been loaded into the working environment (at 2017-03-27 20:02:11)
org.Hs.string
IGRAPH UN-- 18492 728141 -- + attr: name (v/c), seqid (v/c), geneid (v/n), symbol (v/c), | description (v/c), neighborhood_score (e/n), fusion_score (e/n), | cooccurence_score (e/n), coexpression_score (e/n), experimental_score | (e/n), database_score (e/n), textmining_score (e/n), combined_score | (e/n) + edges (vertex names): [1] 3025671--3031737 3021358--3027795 3021358--3027929 3021358--3027741 [5] 3024278--3029186 3029373--3031543 3031543--3034385 3019006--3030823 [9] 3015391--3030823 3021191--3028634 3021191--3024550 3021191--3033402 [13] 3031876--3031959 3015324--3031959 3023108--3033954 3016546--3020273 + ... omitted several edges