This data is prepared based on the molecular signatures database (Msigdb; http://www.broadinstitute.org/gsea/msigdb/index.jsp). An R object that contains associations between Msigdb C2:CGP (chemical and genetic perturbations) gene sets and Human Entrez Genes. C2:CGP gene sets are about expression signatures of genetic and chemical perturbations. A number of these gene sets come in pairs: an xxx_UP (xxx_DN) gene set representing genes induced (repressed) by the perturbation.
org.Hs.egMsigdbC2CGP <- dRDataLoader(RData.customised = "org.Hs.egMsigdbC2CGP")
an object of class "GS", a list with following components:
set_info: a matrix of nSet X 4 containing gene set information, where nSet is the number of gene sets, and the 4 columns are "setID" (i.e. "Geneset standard name"), "name" (i.e. "Geneset brief description"), "namespace" (i.e. Geneset category code) and "distance" (i.e. "Geneset full description")
gs: a list of gene sets, each storing gene members thereof. Always, gene sets are identified by "setID" and gene members identified by "Entrez ID"
Subramanian et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A., 102(43):15545-50.
org.Hs.egMsigdbC2CGP <- dRDataLoader(RData.customised='org.Hs.egMsigdbC2CGP')Error in dRDataLoader(RData.customised = "org.Hs.egMsigdbC2CGP"): unused argument (RData.customised = "org.Hs.egMsigdbC2CGP")names(org.Hs.egMsigdbC2CGP)Error in eval(expr, envir, enclos): object 'org.Hs.egMsigdbC2CGP' not found